PRDX1 stabilizes NFE2L2 by inhibiting cullin 3 (CUL3)-mediated ubiquitination, thereby promoting transcription of genes involved in GSH synthesis ( GCLC , GCLM ) and cystine import ( SLC7A11 ) 113
Thereby, prototype cytoprotective agent gastric pentadecapeptide BPC 157, which has been used in trials for ulcerative colitis and now for multiple sclerosis, would rescue IC lesions in rats (IC rats)
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